Heroin

Heroin is widely used as a (mostly) illegal drug for its intense euphoria, which often disappears with increased tolerance. It is thought that heroin's popularity with recreational users, compared to morphine or other opiates, comes from its somewhat different perceived effects. These come from heroin's high lipid solubility provided by the two acetyl groups, resulting in a very rapid penetration of the blood-brain barrier after use. Heroin can be taken or administered in a number of ways, including snorting and injection. It may also be smoked by inhaling the vapors produced when heated from below (known as "chasing the dragon").

Many users dissolve the drug together with cocaine in a so-called "speedball" or "snowball", which is injected intravenously. This causes an even more intense rush than heroin alone but is more dangerous because the short-acting stimulant with the longer-acting depressant increases the risk of overdosing on one or both drugs. Cocaine is an irritant to all bodily tissues, causing eventual necrosis at any site with which it is in frequent contact.

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